THE UNSWORTH RESEARCH GROUP
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The Group
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Catalysis
Spirocycles
Divergent
Asymmetric
Biocatalysis
Ring Expansion
SuRE
Cascade Ring Expansion
Radicals and Photochemistry
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About Will
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We are interested in the development of new dearomatising spirocyclisation methods, especially those involving alkyne activation with π-acids and metal carbenoid intermedaites.
For selected publications, see:
Merging π-acid and Pd catalysis: dearomatising spirocyclisation/cross coupling cascade reactions of alkyne-tethered aromatics
H. E. Ho, T. C. Stephens, T. J. Payne, P. O’Brien, R. J. K. Taylor, W. P. Unsworth,
ACS Catal.
2019
,
9
, 504–510
Back-to-Front”Indole Synthesis Using Silver(I) Catalysis:Unexpected C‑3 Pyrrole Activation Mode Supported by DFT
A. K. Clarke, J. M. Lynam, R. J. K. Taylor, W. P. Unsworth,
ACS Catal
.
2018
,
8
, 6844
Silica-supported silver nitrate as a highly active dearomatising spirocyclisation catalyst: synergistic alkyne activation by silver nanoparticles and silica
A. K. Clarke, M. J. James, P. O’Brien, R. J. K. Taylor, W. P. Unsworth,
Angew. Chem. Int. Ed.
2016,
55
, 13798–13802
Catalyst-driven scaffold diversity: selective synthesis of spirocycles, carbazoles and quinolines from indolyl ynones
J. T. R. Liddon, M. J. James, A. K. Clarke, P. O'Brien, R. J. K. Taylor, W. P. Unsworth,
Chem. Eur. J.
2016,
22
, 8777–8780.
Silver(I)-Catalyzed Dearomatization of Alkyne-Tethered Indoles: Divergent Synthesis of Spirocyclic Indolenines and Carbazoles
M. J. James, R. E. Clubley, K. Y. Palate, T. J. Procter, A. C. Wyton, P. O’Brien, R. J. K. Taylor, W. P. Unsworth,
Org. Lett
. 2015,
17
, 4372
.
Silver(I)- or Copper(II)-Mediated Dearomatization of Aromatic Ynones: Direct Access to Spirocyclic Scaffolds
M. J. James, J. Cuthbertson, P. O’Brien, R. J. K. Taylor, W. P. Unsworth,
Angew. Chem. Int. Ed
. 2015,
54
, 7640.
Home
The Group
Current Members
Past Members
Group Pictures
Research
Catalysis
Spirocycles
Divergent
Asymmetric
Biocatalysis
Ring Expansion
SuRE
Cascade Ring Expansion
Radicals and Photochemistry
Publications
About Will