83. Expanding the scope of the Successive Ring Expansion strategy for macrocycle and medium-sized ring synthesis: unreactive and reactive lactams Z. Yang, M. Arnoux, D. Hazelard, O. Hughes, J. Nabarro, A. C. Whitwood, M. A Fascione, C. D. Spicer, P. Compain, W. P. Unsworth. Org. Biomol. Chem., 2024, https://doi.org/10.1039/D4OB00285G
82. The genomic and enzymatic basis for iridoid biosynthesis in cat thyme. S. J. Smit, S. Ayten, B. A. Radzikowska, J. P. Hamilton, S. Langer, W. P. Unsworth, T. R. Larson, C. R. Buell, B. R. Lichman, Plant J. 2024 (Teucrium marum). https://doi.org/10.1111/tpj.16698
81. Silver–N-Heterocyclic Carbenes in π–Activation: Synergistic Effects between the Ligand Ring Size and the Anion A. Frith, A. K. Clarke, A. Heyam, J. M. Lynam, P. D. Newman, W. P. Unsworth, C. E. Willans. Organometallics 2024, 43, 5, 598–604
80. A Modular Strategy for the Synthesis of Macrocycles and Medium-Sized Rings via Cyclization/Ring Expansion Cascade Reactions. I. Zalessky, J. M. Wootton, J. K. F. Tam, D. E. Spurling, W. C. Glover-Humphreys, J. R. Donald, W. E. Orukotan, L. C. Duff, B. J. Knapper, A. C. Whitwood, T. F. N. Tanner, A. H. Miah, J. M. Lynam and W. P. Unsworth J. Am. Chem. Soc. 2024, doi.org/10.1021/jacs.4c00659
79. Complementary specificity of unspecific peroxygenases enables access to diverse products from terpene oxygenation. B. Melling, T. Mielke, A. C. Whitwood, T. J. C. O’Riordan, N. Mulholland, J. Cartwright, W. P. Unsworth, G. Grogan Chem Catalysis 2024, 4, 100889
78. Ynones in dearomative spirocyclisation processes; a review. R. J. K. Taylor, W. P. Unsworth Tetrahedron Chem 2024, 9, 100055
2023
77. Divergent Cascade Ring Expansion Reactions of Acryloyl Imides. W. E. Orukotan, K. Y. Palate, B. Pogrányi, P. Bobinski, R. G. Epton, L. Duff, A. C. Whitwood, G. Grogan, J. M. Lynam, W. P. Unsworth. Chem. Eur. J. 2023, 29, e202303270
76. Radical Dearomatising Spirocyclisation of Benzisoxazole-Tethered Ynones. N. Inprung, A. C. Whitwood, R. J. K. Taylor, M. J. James, W. P. Unsworth Eur. J. Org. Chem. 2023, e202300603
75. Ring expansion reactions of P=O-containing Molecules. Z. Yang, J. K. F. Tam, J. M. Wootton, J. M. Lynam, W. P. Unsworth, Chem. Commun. 2023, 59, 7927–7930
74. Ring Expansion Strategies for the Synthesis of Medium Sized Ring and Macrocyclic Sulfonamides. Z. Yang, I. Zalessky, R. G. Epton, A. C. Whitwood, J. M. Lynam, W. P. Unsworth Angew. Chem., Int. Ed. 2023, 62, e202217178
73. Overcoming the lack of authentic standards for the quantification of biogenic secondary organic aerosol markers. D. J. Bryant, A. W. Mayhew, K. L. Pereira, S. H. Budisulistiorini, C. Prior, W. P. Unsworth, D. O. Topping, A. R. Rickard J. F. Hamilton Environ. Sci.: Atmos., 2023, https://doi.org/10.1039/D2EA00074A
72. Preparative-Scale Biocatalytic Oxygenation of N-Heterocycles with a Lyophilized Peroxygenase Catalyst. B. Pogrányi, T. F. Mielke, A. Díaz-Rodriguez, J. Cartwright, W. P Unsworth, G. Grogan Angew. Chem., Int. Ed. 2023, 62, e202214759
2022
71. Comparing the catalytic and structural characteristics of a ‘short’ unspecific peroxygenase (UPO) expressed in P. pastoris and E. coli. W. X. Q. Robinson, T. Mielke, B. Melling, A. Cuetos, A. Parkin, W. P. Unsworth, J. Cartwright, G. Grogan ChemBioChem 2022, https://doi.org/10.1002/cbic.202200558
70. Visible-Light Mediated Energy Transfer Enables the Synthesis of β-Lactams via Intramolecular Hydrogen Atom Transfer. M. J. Oddy, D. A. Kusza, R. G. Epton, J. M. Lynam, W. P. Unsworth, W. F. Petersen Angew. Chem., Int. Ed. 2022, 2022, 61, e202213086
69. A consecutive ring expansion strategy towards the macrocyclic core of the solomonamide natural products. Z. Yang, C. R. B. Swanson, W. P. Unsworth Synlett 2022 DOI: 10.1055/a-1932-9717
68. DFT Studies of Au(I) Catalysed Reactions: Anion Effects and Reaction Selectivity. R. G. Epton, W. P. Unsworth, J. M. Lynam Isr. J. Chem.2022 e202200033
67. Biocatalytic activation of diazirines for carbene-transfer reactions B. Pogrányi, W. P. Unsworth, G. Grogan Chem., 2022 8, 1801-1804
66. Synthesis of medium-ring lactams and macrocyclic peptide mimetics via conjugate addition/ring expansion cascade reactions. K. Y. Palate, Z. Yang, A. C. Whitwood, W. P. Unsworth RSC Chem. Biol., 2022 ASAP
65. Selectivity, Speciation, and Substrate Control in the Gold-Catalyzed Coupling of Indoles and Alkynes. R. G. Epton, W. P. Unsworth, J. M. Lynam Organometallics2022 ASAP
64. Indole-ynones as Privileged Substrates for Radical Dearomatizing Spirocyclization Cascades. N. Inprung, H. E. Ho, J. A. Rossi-Ashton, R. G. Epton, A. C. Whitwood, J. M. Lynam, R. J. K. Taylor, M. J. James, W. P. Unsworth Org. Lett. 2022, 24, 668–674
2021
63. Unprecedented reactions for molecular editing. William. P. Unsworth and Alyssa-Jennifer Avestro Nature2021, 593, 203–204 News and Views article
62. A Thiol-Mediated Three-Step Ring Expansion Cascade for the Conversion of Indoles into Functionalized Quinolines. Nantachai Inprung, Michael J. James,* Richard J. K. Taylor* and William. P. Unsworth* Org. Lett. 2021, 23, 6, 2063–2068
61. Synthesis of macrocyclic and medium-sized ring thiolactones via the ring expansion of lactams Kleopas Y. Palate, Ryan G. Epton, Adrian C. Whitwood, Jason M. Lynam and William P. Unsworth* Org. Biolmol. Chem. 2021https://doi.org/10.1039/D0OB02502J
2020
60. Synthesis of polycyclic scaffolds via a gold-catalysed dearomative cyclisation cascade Aimee K. Clarke,* James A. Rossi-Ashton, Richard J. K. Taylor and William P. Unsworth* Tetrahedron 2020, https://doi.org/10.1016/j.tet.2020.131392
59. Phosphoranyl Radical Fragmentation Reactions Driven by Photoredox Catalysis James A. Rossi-Ashton*, Aimee K. Clarke, William P. Unsworth, and Richard J. K. Taylor ACS Catal. 2020, 10, 7250-7261
58. Evaluating the viability of successive ring expansion reactions based on amino acid and hydroxyacid side chain insertion Aggie Lawer, Ryan G. Epton, Thomas C. Stephens, Kleopas Y. Palate, Mahendar Lodi, Emilie Marotte, Katie J. Lamb, Jade K. Sangha, Jason M. Lynam,* William Paul Unsworth* Chem. Eur. J., 2020, 26, 12674–12683
57. Photocatalytic Deoxygenation of Sulfoxides using Visible Light: Mechanistic Investigations and Synthetic Applications Aimee K Clarke, Alison Parkin, Richard J. K. Taylor*, William P. Unsworth* and James A. Rossi-Ashton* ACS Catal.2020, 10, 5814–5820
56. A happy medium: the synthesis of medicinally important medium-sized rings via ring expansion Aimee K Clarke and William P. Unsworth* Chem. Sci. 2020, 11, 2876-2881
55. Iridium Catalyzed Enantioselective Intermolecular Indole C2-Allylation James A. Rossi-Ashton, Aimee K. Clarke, James R. Donald, Chao Zheng,*Richard J. K. Taylor,* William P. Unsworth,* Shu-Li You* Angew. Chem. Int. Ed. 2020, 59, 7598–7604 Hot Paper
54. Modular Synthesis of Polycyclic Alkaloid Scaffolds via an Enantioselective Dearomative Cascade James A. Rossi-Ashton, Aimee K. Clarke, *Richard J. K. Taylor,* William P. Unsworth,* Org. Lett.2020, 22, 1175-1181
53. Consecutive Ring-Expansion Reactions for the Iterative Assembly of Medium-Sized Rings and Macrocycles Thomas C. Stephens and William P. Unsworth* Synlett 2020, 31, 133-146
52. Visible-light-induced intramolecular charge transfer in the radical spirocyclisation of indole-tethered ynones Hon Eong Ho, Angela Pagano, James A. Rossi-Ashton, James R. Donald, Ryan G. Epton, Jonathan C. Churchill, Michael J. James, Peter O'Brien, Richard J. K. Taylor* and William P. Unsworth* Chem. Sci., 2020,11, 1353-1360
2019
51. A Marine Viral Halogenase that Iodinates Diverse Substrates D. S. Gkotsi, H. Ludewig, S. V. Sharma, W. P. Unsworth, R. J. K. Taylor, M. M. W. McLachlan, S. Shanahan, J. H. Naismith, R. J. M. Goss* Nature Chem. 2019,11, 1091–1097
50. Synthetic and Mechanistic Studies into the Rearrangement of Spirocyclic Indolenines into Quinolines Ryan G. Epton, Aimee K. Clarke, Richard J. K. Taylor, William P. Unsworth* and Jason M. Lynam* Eur. J. Org. Chem. 2019, 5563-5571
49. Internal nucleophilic catalyst mediated cyclisation/ring expansion cascades for the synthesis of medium-sized lactones and lactams Aggie Lawer James A. Rossi‐Ashton Thomas C. Stephens Bradley J. Challis Ryan G. Epton Jason M. Lynam and William P. Unsworth* Angew. Chem. Int. Ed. 2019, 58, 13942-13947
48. Indole Synthesis Using Silver Catalysis Aimee K. Clarke, Hon E. Ho, James A. Rossi‐Ashton, Richard J. K. Taylor and William P. Unsworth* Chem. Asian J. 2019, 14, 1900-1911
47. Merging π-Acid and Pd Catalysis: Dearomatizing Spirocyclization/Cross-Coupling Cascade Reactions of Alkyne-Tethered Aromatics Hon Eong Ho, Thomas C. Stephens, Thomas J. Payne, Peter O’Brien, Richard J. K. Taylor* and William P. Unsworth* ACS Catal.2019, 9, 1, 504-510
2018
46. Understanding the Role of Spiroindolenines in Pictet-Spengler Reactions William P. Unsworth* Chem. 2018, 4, 1767-1770
45. Iterative Assembly of Macrocyclic Lactones using Successive Ring Expansion Reactions Thomas C. Stephens, Aggie Lawer, Thomas French and William P. Unsworth* Chem. Eur. J. 2018, 24, 13947-13953
43. "Back-to-Front" Indole Synthesis using Silver(I) Catalysis: Unexpected C-3 Pyrrole Activation Mode Supported by DFT Aimee K. Clarke, Jason M. Lynam*, Richard J. K. Taylor* and William P. Unsworth* ACS Catal.2018, 8, 6844-6850
41. Divergent reactivity of phenol- and anisole-tethered donor-acceptor α-diazoketones A. K. Clarke, R. J. K. Taylor,* W. P. Unsworth,* Tetrahedron, 2018, 74, 5374–5382
40. Ag(I)-Catalyzed Synthesis of Azabicyclic Alkaloid Frameworks from Ketimine-Tethered Ynones: Total Synthesis of Indolizidine 209D H. E. Ho, M. J. James, P. O’Brien, R. J. K. Taylor,* W. P. Unsworth* Org. Lett. 2018, 20, 1439–1443
2017
39. Selective synthesis of three product classes from imine and carboxylic acid precursors via direct imine acylation J. A. Rossi-Ashton, R. J. K. Taylor,* W. P. Unsworth* Org. Biomol. Chem., 2017, 15, 7527
38. Synthesis of Cyclic Peptide Mimetics by the Successive Ring Expansion of Lactams T. C. Stephens, M. Lodi, A. Steer, Y. Lin, M. Gill, W. P. Unsworth* Chem. Eur. J. 2017, 23, 13314–13318
37. Ring-Expansion Reactions in the Synthesis of Macrocycles and Medium-Sized Rings W. P. Unsworth,* J. R. Donald Chem. Eur. J. 2017, 23, 8780
36. Ring expansion approach to medium-sized lactams and analysis of their medicinal lead-like properties L. G. Baud, M. A. Manning, H. L. Arkless, T. C. Stephens, W. P. Unsworth Chem. Eur. J. 2017, 23, 2225.
35. Dearomatisation approaches to spirocyclic dienones via the electrophilic activation of alkynes A. K. Clarke, J. T. R. Liddon, J. D. Cuthbertson, R. J. K. Taylor,* W. P. Unsworth* Org. Biomol. Chem., 2017, 15, 233–245.
2016
34. Catalytic Dearomatization Approach to Quinolizidine Alkaloids: Five Step Total Synthesis of (±)-Lasubine II M. J. James, N. D. Grant, Peter O’Brien, R. J. K. Taylor,* W. P. Unsworth* Org.Lett. 2016, 18, 6256−6259
33. Preparation and Reactions of Indoleninyl Halides: Scaffolds for the Synthesis of Spirocyclic Indole Derivatives J. T. R. Liddon, A. K. Clarke, R. J. K. Taylor,* W. P. Unsworth* Org. Lett.2016, 18, 6328−6331
32. Silica-supported silver nitrate as a highly active dearomatising spirocyclisation catalyst: synergistic alkyne activation by silver nanoparticles and silica A. K. Clarke, M. J. James, P. O’Brien, R. J. K. Taylor,* W. P. Unsworth* Angew. Chem. Int. Ed. 2016, 55, 13798–13802
31. Phosphorylated cyclopropanes in the synthesis of α-alkylidene-γ-butyrolactones: total synthesis of (±)-savinin, (±)-gadain and (±)-peperomin E M. G. Lloyd, R. J. K. Taylor,* W. P. Unsworth* Org. Biomol. Chem. 2016, 14, 8971–8988
30. Selective Synthesis of Six Products from a Single Indolyl α-Diazocarbonyl Precursor M. J. James, P. O’Brien, R. J. K. Taylor,* W. P. Unsworth* Angew. Chem. Int. Ed. 2016, 54, 9671–9675
29. Direct Imine Acylation: A Versatile Method for the Synthesis of Nitrogen-Containing Heterocycles, Spirocycles and Natural Products W. P. Unsworth,* R. J. K. Taylor* Synlett 2016, 27, 2051–2064
28. Synthetic approaches to pallimamine and analogues using direct imine acylation T. O. Ronson, C. Kitsiou, W. P. Unsworth, R. J. K. Taylor* Tetrahedron2016, 72, 6099–6106
27. Catalyst-Driven Scaffold Diversity: Selective Synthesis of Spirocycles, Carbazoles and Quinolines from Indolyl Ynones J. T. R. Liddon, M. J. James, A. K. Clarke, P. O’Brien, R. J. K. Taylor, W. P. Unsworth Chem. Eur. J. 2016, 22, 8777–8780.
26. From Heteroaromatic Acids and Imines to Azaspirocycles: Stereoselective Synthesis and 3D Shape Analysis S.J. Chambers, G. Coulthard, W. P. Unsworth, P. O’Brien, R. J. K. Taylor* Chem. Eur. J. 2016, 22, 6496–6500
25. A selective C–H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural products M. G. Lloyd, M. D’Acunto, R. J. K. Taylor,* W. P. Unsworth* Org. Biomol. Chem. 2016, 14, 1641–1645
24. Synthesis of Spirocyclic Indolenines M. J. James, P. O’Brien, R. J. K. Taylor, W. P. Unsworth Chem. Eur. J. 2016 22, 2856–2881
23. Synthetic Studies towards the Africanane Sesquiterpenes via the Cope Rearrangement of gem-Dimethyl-Substituted Divinyl Cyclopropanes J. D. Osler, W. P. Unsworth,* R. J. K. Taylor* Synlett, 2016, 27, 70–74
2015
22. The Synthesis of Structurally Diverse Macrocycles By Successive Ring Expansion C. Kitsiou, J. J. Hindes, P. I’Anson, P. Jackson, T. C. Wilson, E. K. Daly, H. R. Felstead, P. Hearnshaw, W. P. Unsworth Angew. Chem. Int. Ed. 2015, 54, 15794 –15798
21. Silver(I)-Catalyzed Dearomatization of Alkyne-Tethered Indoles: Divergent Synthesis of Spirocyclic Indolenines and Carbazoles M. J. James, R. E. Clubley, K. Y. Palate, T. J. Procter, A. C. Wyton, P. O’Brien, R. J. K. Taylor, W. P. Unsworth Org. Lett. 2015, 17, 4372
20. Silver(I)- or Copper(II)-Mediated Dearomatization of Aromatic Ynones: Direct Access to Spirocyclic Scaffolds M. J. James, J. Cuthbertson, P. O’Brien, R. J. K. Taylor,* W. P. Unsworth* Angew. Chem. Int. Ed. 2015, 54, 7640–7643
19. Propylphosphonic anhydride (T3P) mediated synthesis of β-lactams from imines and aryl-substituted acetic acids G. Coulthard, W. P. Unsworth, R. J. K. Taylor* Tetrahedron Lett, 2015, 56, 3113–3116
18. The total synthesis of (+)-elaeokanidine A: natural product or isolation artefact? J. D. Cuthbertson, W. P. Unsworth, C. L. Moody, R. J. K. Taylor* Tetrahedron Lett, 2015, 56, 3123–3126
17. α-Alkylidene-γ-butyrolactone synthesis via one-pot C–H insertion/olefination: substrate scope and the total synthesis of (±)-cedarmycins A and B M. G. Lloyd, M. D’Acunto, R. J. K. Taylor,* W. P. Unsworth* Tetrahedron, 2015, 71, 7107–7123
2014
16. Rhodium(II)-catalysed tandem aziridination and ring-opening: stereoselective synthesis of functionalised tetrahydrofurans W. P. Unsworth, T. Ronson, N. Clark, K. Stevens, A. L. Thompson, S. Lamont, J. Robertson* Chem. Commun. 2014, 50, 11393–11396
15. Substrate scope and stereocontrol in the Rh(II)-catalysed oxyamination of allylic carbamates W. P. Unsworth, S. G. Lamont, J. Robertson* Tetrahedron2014, 70, 7388–7394
14. Substrate scope in the direct imine acylation of ortho-substituted benzoic acid derivatives: the total synthesis (±)-cavidine C. Kitsiou, W. P. Unsworth, G. Coulthard, R. J. K. Taylor* Tetrahedron2014, 70, 7172–7180
13. A One-Pot C–H Insertion/Olefination Sequence for the Formation of α-Alkylidene-γ-butyrolactones M. G. Lloyd, R. J. K. Taylor,* W. P. Unsworth* Org. Lett. 2014,16, 2772
12. Direct Imine Acylation for Molecular Diversity in Heterocyclic Synthesis W. P. Unsworth, G. Coulthard, C. Kitsiou, and R. J. K. Taylor* J. Org. Chem., 2014, 79, 1368–1376
2013
11. The Cope rearrangement of gem-dimethyl substituted divinylcyclopropanes J. D. Osler, W. P. Unsworth, R. J. K. Taylor* Org. Biomol. Chem. 2013, 11, 7587–7594
9. Total Synthesis of Spirobacillene A W. P. Unsworth,* J. D. Cuthbertson, R. J. K. Taylor* Org. Lett. 2013, 15, 3306–3309
8. An Expedient Protecting-Group-Free Total Synthesis of (±)-Dievodiamine W. P. Unsworth,* C. Kitsiou, R. J. K. Taylor* Org. Lett. 2013, 15, 3302–3305
7. Direct Imine Acylation: Synthesis of the Proposed Structures of ‘Upenamide W. P. Unsworth, K. A. Gallagher, M. Jean, J. P. Schmidt, L. J. Diorazio, R. J. K. Taylor* Org. Lett. 2013, 15, 262–265
6. Direct Imine Acylation: Rapid Access to Diverse Heterocyclic Scaffolds W. P. Unsworth, C. Kitsiou, R. J. K. Taylor* Org. Lett. 2013, 15, 258–261
2012 and earlier
5. Alkyne-acetal cyclisation reactions mediated by formic acid; 3-acylated-2,5-dihydrofurans and related oxygen and nitrogen heterocycles J. D. Cuthbertson, A. A. Godfrey, W. P. Unsworth, R. J. K. Taylor* Heterocycles2012, 84, 1013–1021
4. Stereospecificity in the Au-catalysed cyclisation of monoallylic diols. Synthesis of (+)-isoaltholactone W. P. Unsworth, K. Stevens, S. G. Lamont, J. Robertson* Chem. Commun. 2011, 47, 7659–7661
3. Aspects of stereocontrol in the L-Selectride reduction of 4-acyl-1,3-dioxolane derivatives J. Robertson,* W. P. Unsworth, S. G. Lamont Tetrahedron 2010, 66, 2363
2. Radical 1,4-aryl transfer in arylcarboxamides leading to phthalimides, biaryls and enantiomerically enriched β-arylethylamines J. Robertson,* M. J. Palframan, S. A. Shea, K. Tchabanenko, W. P. Unsworth, C. Winters Tetrahedron 2008, 64, 11896–11907