End-to-end cyclisation reactions (1 to 2) to make medium-sized rings/macrocycles are typically inefficient. We believe that by designing reaction sequences such that overall end-to-end cyclisation is achieved via cyclisation/ring expansion cascades (3 to 4 to 5) a more kinetically favourable reaction course can be followed. This has been demostrated in our proof of concept study for the atroposelective synthesis of medium-sized rings 8. Expanding upon this idea will be a major research focus for the Unsworth group in the coming years.